PCN133 Effects of Trial Population Selection on Modeled Incremental Quality of Life and Healthcare Decision-Making: A Systematic Review and Example in Selective Internal Radiation Therapy for the Treatment of Hepatocellular Carcinoma

Measuring and modeling patient quality of life is critically important in the evaluation cost-effectiveness any health intervention, with arguably being most consideration patients for whom a meaningful extension not feasible. In present study, we aimed to identify cost-utility analyses comparing selective internal radiation therapy (SIRT) systemic unresectable hepatocellular carcinoma (HCC) compare modeled incremental differences between two therapies. A systematic literature review was conducted. PubMed, EMBASE, Cochrane Library, technology assessment agency websites were searched studies SIRT versus therapies treatment HCC. Incremental outcomes extracted from included studies, magnitudes measures ranked descending order illustrate range distribution values. The retrieved 1,140 which four ultimately included, plus identified hand searches. From six 13 considered, estimates spanning -0.09 +0.28 quality-adjusted years (QALYs) based on analysis using data overall trial populations, or +0.60 QALYs when also considering post hoc sub-group analyses. wide QALYs, substantial populations subgroups, illustrates impact choice target population may have results. It highlights both importance reporting dispersion around findings, limitations ratio (ICER) assessing relative interventions that are predicted result similar outcomes.